Letrozole: How It Works & Side Effects

But, alcohol can cause side effects similar to those of letrozole. Here’s a list of common questions related to taking letrozole. Your doctor or pharmacist may be able to recommend a pharmacy that offers these options if your current pharmacy doesn’t. Talk with your doctor if you have more questions about the differences and similarities between letrozole and tamoxifen. If you’re having severe tooth or jaw pain, call your doctor and ask them about treatment options.

Consideration should be given to monitoring bone mineral density see Warnings and Precautions (5.1). Letrozole was superior to tamoxifen in TTP and rate of objective tumor response (see Table 12). 2Stratified log-rank test, stratified by receptor status, nodal status and prior chemotherapy.

Both Femara and Arimidex belong to a group of drugs called aromatase inhibitors. The drugs work by lowering estrogen levels in your body, which helps stop breast cancer from growing. Femara belongs to a group of drugs called aromatase inhibitors.

1 Clinical Trials Experience

The incidence of new osteoporosis was 14.5% for letrozole and 7.8% for placebo. Based on a median follow-up of patients for 28 months, the incidence of clinical fractures from the core randomized study in patients who received letrozole was 5.9% (152) and placebo was 5.5% (142). The incidence of self-reported osteoporosis was higher in patients who received letrozole 6.9% (176) than in patients who received placebo 5.5% (141). Bisphosphonates were administered to 21.1% of the patients who received letrozole and 18.7% of the patients who received placebo. No dose-related effect of letrozole on any hematologic or clinical chemistry parameter was evident.

What should I know about letrozole vs. anastrozole?

The use of https://courses.iskconmangaluru.com/steroids-before-and-after-understanding-the-impact-31/ the information on this website does not create a physician-patient relationship between Cancer Care Ontario and you. Letrozole is a nonsteroidal competitive inhibitor of the aromatase enzyme system; it inhibits the conversion of androgens to estrogens. In adult nontumor- and tumor-bearing female animals, letrozole is as effective as ovariectomy in reducing uterine weight, elevating serum LH, and causing the regression of estrogen-dependent tumors. In contrast to ovariectomy, treatment with letrozole does not lead to an increase in serum FSH.

• Find Clinical Trials for Letrozole – Check for trials from NCI’s list of cancer clinical trials now accepting patients.
• You may have bone density (DEXA) scans to check how strong your bones are, before you start taking letrozole, 1 or 2 years into treatment and again after you finish your treatment.
• Femara (letrozole) is a non-steroidal aromatase inhibitor (lowers estrogen production) used to treat breast cancer in postmenopausal women.

This compound, CGS 20267, now known as letrozole, was a third-generation, nonsteroidal aromatase inhibitor (1). Letyrozole was approved to be effective for a wide range of breast cancer settings, which at present it’s only registered indication (2). In 1993, letrozole was initially used in animal ovulation induction (OI) (3).